Formal Synthesis of (±)-Platensimycin
نویسندگان
چکیده
منابع مشابه
Chemoenzymatic Enantioselective Formal Synthesis of (-)-Gephyrotoxin-223
(-)-Gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized in the presence of Candida Antartica lipase.
متن کاملPlatensimycin: a promising antimicrobial targeting fatty acid synthesis.
Platensimycin was recently discovered by Merck Research Laboratories and has created considerable interest given its potent antibacterial activity and mode of action. The use of RNA gene-silencing techniques and screening libraries of natural products allowed Merck to find this antibiotic which may have otherwise been missed using conventional methods. Interestingly, platensimycin has shown goo...
متن کاملchemoenzymatic enantioselective formal synthesis of (-)-gephyrotoxin-223
(-)-gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized in the presence of candida antartica lipase.
متن کاملThe Chemistry and Biological Activity of Platensimycin
Hospital mortalities from multidrug-resistant bacteria have grown in recent years. Multidrugresistant bacteria are becoming a major public health crisis because the antibiotics that exist today are no longer effective in all cases. Drugs, like vancomycin, which were once last-resort treatments are quickly becoming a first-line defense because the over-prescription of antibiotics is allowing for...
متن کاملFormal total synthesis of triptolide.
A new approach to the medicinally-important natural product triptolide is significantly shorter than previous syntheses, highly convergent and avoids the use of protecting groups; key features include two Diels-Alder reactions and a new deoxygenative aromatisation process.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2007
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol070563g